Article
Mitochondrial DNA mutations and aging.
Annals of the New York Academy of Sciences - 1 Apr 2007
Krishnan Kim J, Greaves Laura C, Reeve Amy K, Turnbull Douglass M
Abstract excerpt
Mitochondria have been hypothesized to play a role in both aging and neurodegenerative diseases, such as Parkinson's disease (PD) and Alzheimer's disease. Many studies have shown the accumulation of mitochondrial DNA (mtDNA) mutations in post-mitotic tissues and more recent data have shown this also to be a feature of aging mitotic tissues. Much of this data has been correlative, until recently with the...
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