Article
Mitochondrial genetics: a paradigm for aging and degenerative diseases?
Science (New York, N.Y.) - 1 May 1992
Wallace D C
Abstract excerpt
Studies of diseases caused by mitochondrial DNA mutations suggest that a variety of degenerative processes may be associated with defects in oxidative phosphorylation (OXPHOS). Application of this hypothesis has provided new insights into such diverse clinical problems as ischemic heart disease, late-onset diabetes, Parkinson's disease, Alzheimer's disease, and aging.
Topics
- Aging
- Alzheimer Disease
- Base Sequence
- Coronary Disease
- DNA, Mitochondrial
- Humans
- Huntington Disease
- Molecular Sequence Data
- Muscular Diseases
- Mutation
- Nervous System Diseases
- Oxidative Phosphorylation