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Article

Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.

PLoS medicine - 1 Apr 2007

Nomura Masaharu, Shigematsu Hisayuki, Li Lin, Suzuki Makoto, Takahashi Takao, Estess Pila, Siegelman Mark, Feng Ziding, Kato Harubumi, Marchetti Antonio, Shay Jerry W, Spitz Margaret R, Wistuba Ignacio I, Minna John D, Gazdar Adi F

Abstract excerpt

BACKGROUND: The epidermal growth factor receptor (EGFR) gene is the prototype member of the type I receptor tyrosine kinase (TK) family and plays a pivotal role in cell proliferation and differentiation. There are three well described polymorphisms that are associated with increased protein production in experimental systems: a polymorphic dinucleotide repeat (CA simple sequence repeat 1 [CA-SSR1]) in intron one...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17455987
DOI: 10.1371/journal.pmed.0040125
PMCID: PMC1876407

Genes

EGFR
SSR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Polymorphisms, mutations, and amplification of the EGFR gene in non-small cell lung cancers.PMID 17455987Read ↗

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