Article
A meta-analytic review of the CYP2A6 genotype and smoking behavior.
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco - 1 Apr 2004
Carter Brian, Long Tracy, Cinciripini Paul
Abstract excerpt
Individuals who carry variant alleles of the CYP2A6 gene are poor metabolizers of nicotine and are believed to be more sensitive to nicotine's aversive effects than those with normal alleles. This sensitivity is hypothesized to exert a protective effect against smoking initiation and lead to lower cigarette consumption among smokers with variant alleles. Although early studies found an association between variant...
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