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Article

Catechol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents.

Psychiatric genetics - 1 Aug 2010

Walder Deborah J, Trotman Hanan D, Cubells Joseph F, Brasfield Joy, Tang Yi-Lang, Walker Elaine F

Abstract excerpt

OBJECTIVE: Recent research implicates the catechol-O-methyltransferase (COMT) ValMet polymorphism in stress sensitivity, through modulation of hypothalamic-pituitary-adrenal (HPA) function. In healthy samples, Met homozygosity has been associated with greater HPA activity (i.e., cortisol) and stress sensitivity, though findings are mixed among clinical samples. To date, there are no reports examining baseline or...

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Identifiers

PMID: 20421850
DOI: 10.1097/YPG.0b013e32833a1ff3
PMCID: PMC3522124

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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