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Article

Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.

Environmental health perspectives - 1 Apr 2007

Wu Hao, Romieu Isabelle, Sienra-Monge Juan-Jose, del Rio-Navarro Blanca Estela, Anderson Daniel M, Dunn Erin W, Steiner Lori L, Lara-Sanchez Irma del Carmen, London Stephanie J

Abstract excerpt

BACKGROUND: Polymorphisms in the proinflammatory cytokine genes tumor necrosis factor-alpha (TNF) and lymphotoxin-alpha (LTA, also called TNF-beta) have been associated with asthma and atopy in some studies. Parental smoking is a consistent risk factor for childhood asthma. Secondhand smoke and ozone both stimulate TNF production. OBJECTIVES: Our goal was to investigate whether genetic variation in TNF and LTA is...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17450233
DOI: 10.1289/ehp.9740
PMCID: PMC1852663

Genes

TNF
LTA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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