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Article

Associations of tumor necrosis factor G-308A with childhood asthma and wheezing.

American journal of respiratory and critical care medicine - 1 May 2006

Li Yu-Fen, Gauderman W James, Avol Ed, Dubeau Louis, Gilliland Frank D

Abstract excerpt

RATIONALE: Tumor necrosis factor (TNF) mediates a spectrum of airway inflammatory responses, including those to air pollutants, and is an asthma candidate gene. One TNF promoter variant (G-308A) affects expression of TNF and has been associated with inflammatory diseases; however, studies of asthma have been inconsistent. Because ozone produces oxidative stress, increased airway TNF, and inflammation, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16456144
DOI: 10.1164/rccm.200508-1256OC
PMCID: PMC2662916

Genes

TNF
GSTP1
GSTM1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Associations of tumor necrosis factor G-308A with childhood asthma and wheezing.PMID 16456144Read ↗

Ambient ozone modifies the effect of tumor necrosis factor G-308A on bronchitic symptoms among children with asthma.Semantic proximity Read ↗

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Parental smoking modifies the relation between genetic variation in tumor necrosis factor-alpha (TNF) and childhood asthma.Semantic proximity Read ↗

The -308 G/A polymorphism in TNF-α gene is associated with asthma risk: an update by meta-analysis.Semantic proximity Read ↗

Association of tumor necrosis factor-alpha polymorphisms and ozone-induced change in lung function.Semantic proximity Read ↗

Tumor Necrosis Factor-α (-308G>A) Gene Polymorphism and Its Association with Asthma and Atopy Status.Semantic proximity Read ↗

Impact of single nucleotide polymorphism in tumor necrosis factor-α gene 308G/A in Egyptian asthmatic children and wheezing infants.Semantic proximity Read ↗

Relation between tumour necrosis factor polymorphism TNFalpha-308 and risk of asthma.Semantic proximity Read ↗

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An association between asthma and TNF-308G/A polymorphism: meta-analysis.Semantic proximity Read ↗

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