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Article

Association between TNFA Polymorphism and the Development of Asthma in the Japanese Population

1 Jul 2002

Abstract excerpt

Tumor necrosis factor (TNF) is a proinflammatory cytokine that participates in the inflammatory reaction in patients with asthma. The TNFA and TNFB genes, which encode TNF-alpha and TNF-beta, respectively, are located within the region encoding the human major histocompatibility complex on chromosome 6p21.3, which showed linkage to atopic asthma in our genome-wide search. To determine whether polymorphisms in the...

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PMID: 12091169
DOI: 10.1164/rccm.2110052

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