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Article

Biochemical consequences of the NOS3 Glu298Asp variation in human endothelium: altered caveolar localization and impaired response to shear.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Sept 2007

Joshi Mandar S, Mineo Chieko, Shaul Philip W, Bauer John Anthony

Abstract excerpt

Human endothelial nitric oxide synthase (NOS3) gene polymorphism at Exon 7 (Glu298Asp) has been linked to vascular endothelial dysfunction, but the mechanisms are not defined. Shear is a key modulator of NOS3 function in vivo and association with caveolae is important for the control of NOS3 protein activity. Here we tested the hypothesis that altered enrichment of NOS3 in the caveolar membrane defines Glu298Asp...

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Source

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Identifiers

PMID: 17449720
DOI: 10.1096/fj.06-7088com
PMCID: PMC7460804

Genes

NOS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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