Article
Roles of ATP-sensitive K+ channels in cell survival and differentiation in the endocrine pancreas.
Diabetes - 1 Feb 2001
Miki T, Iwanaga T, Nagashima K, Ihara Y, Seino S
Abstract excerpt
To determine the roles of the ATP-sensitive K+ (K(ATP)) channels in endocrine pancreas more directly, two types of genetically engineered Kir6.2 mice were developed: mice expressing a dominant-negative form of Kir6.2 specifically in beta-cells (Kir6.2G132S Tg mice) and mice lacking Kir6.2 (Kir6.2...
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