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Article

DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.

The Journal of biological chemistry - 15 Jun 2007

Masuda Keiji, Ouchida Rika, Hikida Masaki, Kurosaki Tomohiro, Yokoi Masayuki, Masutani Chikahide, Seki Mineaki, Wood Richard D, Hanaoka Fumio, O-Wang Jiyang

Abstract excerpt

Somatic hypermutation of the Ig genes requires the activity of multiple DNA polymerases to ultimately introduce mutations at both A/T and C/G base pairs. Mice deficient for DNA polymerase eta (POLH) exhibited an approximately 80% reduction of the mutations at A/T, whereas absence of polymerase (P...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17449470
DOI: 10.1074/jbc.M611849200

Genes

POLH
POLQ

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17449470-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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DNA polymerases eta and theta function in the same genetic pathway to generate mutations at A/T during somatic hypermutation of Ig genes.PMID 17449470Read ↗

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Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.Semantic proximity Read ↗

DNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.Semantic proximity Read ↗

DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouseSemantic proximity Read ↗

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