Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse

Abstract excerpt

The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase eta, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V patients. Breeding these mice with animals harboring the stop codon mutation of the 129/Olain background in their...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Carcinogens and Genotoxicity Assessment
• Share to DNA Repair Mechanisms
• Share to Genetic factors in colorectal cancer