Article
Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4.
The Journal of biological chemistry - 6 Aug 2004
Okunade Gbolahan W, Miller Marian L, Pyne Gail J, Sutliff Roy L, O'Connor Kyle T, Neumann Jonathan C, Andringa Anastasia, Miller Daniel A, Prasad Vikram, Doetschman Thomas, Paul Richard J, Shull Gary E
Abstract excerpt
The relative importance of plasma membrane Ca2+-ATPase (PMCA) 1 and PMCA4 was assessed in mice carrying null mutations in their genes (Atp2b1 and Atp2b4). Loss of both copies of the gene encoding PMCA1 caused embryolethality, whereas heterozygous mutants had no overt disease phenotype. Despite widespread and abundant expression of PMCA4, PMCA4 null (Pmca4-/-) mutants exhibited no embryolethality and appeared...
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