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Article

Short-hairpin RNA-mediated stable silencing of Grb2 impairs cell growth and DNA synthesis.

Biochemical and biophysical research communications - 8 Jun 2007

Di Fulvio Mauricio, Henkels Karen M, Gomez-Cambronero Julian

Abstract excerpt

Grb2 is an SH2-SH3 protein adaptor responsible for linking growth factor receptors with intracellular signaling cascades. To study the role of Grb2 in cell growth, we have generated a new COS7 cell line (COS7(shGrb2)), based on RNAi technology, as null mutations in mammalian Grb2 genes are lethal...

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Identifiers

PMID: 17445773
DOI: 10.1016/j.bbrc.2007.04.013
PMCID: PMC2247433

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17445773-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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