Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.

Developmental biology - 1 Jun 1999

Burdon T, Stracey C, Chambers I, Nichols J, Smith A

Abstract excerpt

The propagation of pluripotent mouse embryonic stem (ES) cells depends on signals transduced through the cytokine receptor subunit gp130. Signalling molecules activated downstream of gp130 in ES cells include STAT3, the protein tyrosine phosphatase SHP-2, and the mitogen-activated protein kinases...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium-Calmodulin-Dependent Protein Kinases
Share to Cytokine Receptor gp130
Share to Flavonoids

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Helminth Proteins

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 11

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Source

Identifiers

PMID: 10364425
DOI: 10.1006/dbio.1999.9265

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-10364425-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells.PMID 10364425Read ↗

Cytokine signalling in embryonic stem cellsSemantic proximity Read ↗

Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory PathwaySemantic proximity Read ↗

STAT3 is dispensable for maintenance of self-renewal in nonhuman primate embryonic stem cells.Semantic proximity Read ↗

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways.Semantic proximity Read ↗

Molecular genetic analysis of FGFR1 signalling reveals distinct roles of MAPK and PLCgamma1 activation for self-renewal of adult neural stem cells.Semantic proximity Read ↗

Acquiring signalling specificity from the cytokine receptor gp130.Semantic proximity Read ↗

MEK kinase 1 is essential for Bcr-Abl-induced STAT3 and self-renewal activity in embryonic stem cells.Semantic proximity Read ↗

Constitutive and specific activation of STAT3 by BCR-ABL in embryonic stem cells.Semantic proximity Read ↗

The survival of differentiating embryonic stem cells is dependent on the SCF-KIT pathway.Semantic proximity Read ↗

Thrombopoietin acts synergistically with LIF to maintain an undifferentiated state of embryonic stem cells homozygous for a Shp-2 deletion mutation.Semantic proximity Read ↗

BCR-ABL induces opposite phenotypes in murine ES cells according to STAT3 activation levels.Semantic proximity Read ↗

Regulation of interleukin-6 cytokine responses by mitogen activated protein kinasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.