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Article

Involvement of the betaTrCP in the ubiquitination and stability of the HIV-1 Vpu protein.

Biochemical and biophysical research communications - 8 Jun 2007

Belaïdouni Nadia, Marchal Christelle, Benarous Richard, Besnard-Guérin Corinne

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Vpu protein binds to the CD4 receptor and targets it to the proteasome for degradation. This process requires the recruitment of human betaTrCP, a component of the Skp1-Cullin-F box (SCF) ubiquitin ligase complex, that interacts with phosphorylated...

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Identifiers

PMID: 17445772
DOI: 10.1016/j.bbrc.2007.03.195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17445772-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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