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Article

The HIV-1 Vpu protein induces apoptosis in Drosophila via activation of JNK signaling.

PloS one - 1 Jan 2012

Marchal Christelle, Vinatier Gérald, Sanial Matthieu, Plessis Anne, Pret Anne-Marie, Limbourg-Bouchon Bernadette, Théodore Laurent, Netter Sophie

Abstract excerpt

The genome of the human immunodeficiency virus type 1 (HIV-1) encodes the canonical retroviral proteins, as well as additional accessory proteins that enhance the expression of viral genes, the infectivity of the virus and the production of virions. The accessory Viral Protein U (Vpu), in particular, enhances viral particle production, while also promoting apoptosis of HIV-infected human T lymphocytes. Some Vpu...

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Identifiers

PMID: 22479597
DOI: 10.1371/journal.pone.0034310
PMCID: PMC3315533

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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