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Article

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.

Nature cell biology - 1 Aug 2001

Dai R M, Li C C

Abstract excerpt

The ubiquitin-proteasome (Ub-Pr) degradation pathway regulates many cellular activities, but how ubiquitinated substrates are targeted to the proteasome is not understood. We have shown previously that valosin-containing protein (VCP) physically and functionally targets the ubiquitinated nuclear factor kappaB inhibitor, IkappaBalpha to the proteasome for degradation. VCP is an abundant and a highly conserved...

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Source

Identifiers

PMID: 11483959
DOI: 10.1038/35087056

Genes

VCP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.PMID 11483959Read ↗

Valosin-Containing Protein (VCP): A Review of Its Diverse Molecular Functions and Clinical Phenotypes.Semantic proximity Read ↗

Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system.Semantic proximity Read ↗

The VCP/p97 system at a glance: connecting cellular function to disease pathogenesisSemantic proximity Read ↗

Valosin containing protein (VCP): initiator, modifier, and potential drug target for neurodegenerative diseases.Semantic proximity Read ↗

Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in CancerSemantic proximity Read ↗

p97/valosin-containing protein (VCP) is highly modulated by phosphorylation and acetylation.Semantic proximity Read ↗

Complex of Fas-associated factor 1 (FAF1) with valosin-containing protein (VCP)-Npl4-Ufd1 and polyubiquitinated proteins promotes endoplasmic reticulum-associated degradation (ERAD).Semantic proximity Read ↗

Valosin-Containing Protein (VCP)/p97 Oligomerization.Semantic proximity Read ↗

VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease.Semantic proximity Read ↗

Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.Semantic proximity Read ↗

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.Semantic proximity Read ↗

p37 regulates VCP/p97 shuttling and functions in the nucleus and cytosol.Semantic proximity Read ↗

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