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Article

MDM2 is a novel E3 ligase for HIV-1 Vif

7 Jan 2009

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Vif plays a crucial role in the viral life cycle by antagonizing a host restriction factor APOBEC3G (A3G). Vif interacts with A3G and induces its polyubiquitination and subsequent degradation via the formation of active ubiquitin ligase (E3) complex with Cullin5-ElonginB/C. Although Vif itself is also ubiquitinated and degraded rapidly in infected cells, precise...

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PMID: 19128510
DOI: 10.1186/1742-4690-6-1

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MDM2 is a novel E3 ligase for HIV-1 VifPMID 19128510Read ↗

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