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Article

Study of genetic variation in the STAT3 on obesity and insulin resistance in male adults.

Obesity (Silver Spring, Md.) - 1 Jul 2008

Gianotti Tomas F, Sookoian Silvia, Gemma Carolina, Burgueño Adriana L, González Claudio D, Pirola Carlos J

Abstract excerpt

Signal transducer and activator of transcription 3 (STAT3) plays an important role in hepatic glucose homeostasis and carbohydrate metabolism and has been implicated in the leptin-mediated energy homeostasis. We explored whether STAT3 gene variants are associated with obesity and insulin resistance in a well-characterized sample of 984 adult men (aged 34.4+/-8.6 years) of self-reported European ancestry from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18451776
DOI: 10.1038/oby.2008.250

Genes

STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Study of genetic variation in the STAT3 on obesity and insulin resistance in male adults.PMID 18451776Read ↗

Common STAT3 variants are not associated with obesity or insulin resistance in female twins.Semantic proximity Read ↗

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Association of STAT3 common variations with obesity and hypertriglyceridemia: protective and contributive effects.Semantic proximity Read ↗

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Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.Semantic proximity Read ↗

Dietary saturated fat modulates the association between STAT3 polymorphisms and abdominal obesity in adults.Semantic proximity Read ↗

Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents.Semantic proximity Read ↗

Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.Semantic proximity Read ↗

The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.Semantic proximity Read ↗

No conclusive evidence for association of polymorphisms in the adiponectin receptor 1 gene, AdipoR1, with common obesity.Semantic proximity Read ↗

INSIG2 promoter variant, obesity markers and lipid parameters - No association in a large Slavonic Caucasian population sample.Semantic proximity Read ↗

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