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Article

Autophagy and cell death of Purkinje cells overexpressing Doppel in Ngsk Prnp-deficient mice.

Brain pathology (Zurich, Switzerland) - 1 Jan 2010

Heitz Stéphane, Grant Nancy J, Leschiera Raphael, Haeberlé Anne-Marie, Demais Valérie, Bombarde Guy, Bailly Yannick

Abstract excerpt

In Ngsk prion protein (PrP)-deficient mice (NP(0/0)), ectopic expression of PrP-like protein Doppel (Dpl) in central neurons induces significant Purkinje cell (PC) death resulting in late-onset ataxia. NP(0/0) PC death is partly prevented by either knocking-out the apoptotic factor BAX or overexpressing the anti-apoptotic factor BCL-2 suggesting that apoptosis is involved in Dpl-induced death. In this study,...

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Identifiers

PMID: 19055638
DOI: 10.1111/j.1750-3639.2008.00245.x
PMCID: PMC8094811

Genes

BAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autophagy and cell death of Purkinje cells overexpressing Doppel in Ngsk Prnp-deficient mice.PMID 19055638Read ↗

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Deletion of N-terminal residues 23-88 from prion protein (PrP) abrogates the potential to rescue PrP-deficient mice from PrP-like protein/doppel-induced Neurodegeneration.Semantic proximity Read ↗

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