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Article

Doppel-induced Purkinje cell death is stoichiometrically abrogated by prion protein.

Biochemical and biophysical research communications - 9 Jul 2004

Yamaguchi Naohiro, Sakaguchi Suehiro, Shigematsu Kazuto, Okimura Nobuhiko, Katamine Shigeru

Abstract excerpt

Mice devoid of prion protein (PrP) exhibiting ataxia and Purkinje cell degeneration, such as Ngsk Prnp(-/-) mice, ectopically express PrP-like protein, Dpl, in neurons including Purkinje cells. In this study, two types of transgenic (tg) mice expressing Dpl in neurons, tg(N-Dpl), or Purkinje cells only, tg(P-Dpl), were generated on the background of non-ataxic Zrch I Prnp(-/-) mice. In contrast to the tg mice...

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Identifiers

PMID: 15194501
DOI: 10.1016/j.bbrc.2004.05.115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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