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Article

A variant in the cytochrome p450 oxidoreductase gene is associated with breast cancer risk in African Americans.

Cancer research - 15 Apr 2007

Haiman Christopher A, Setiawan V Wendy, Xia Lucy Y, Le Marchand Loïc, Ingles Sue A, Ursin Giske, Press Michael F, Bernstein Leslie, John Esther M, Henderson Brian E

Abstract excerpt

Variation in the cytochrome P450 oxidoreductase (POR) gene, a key regulator of type II cytochrome P450 enzymes, may affect exposure to endogenous steroid hormones and breast cancer risk. We sequenced the POR locus and tested candidate polymorphisms G5G and A503V for association with breast cancer risk among women in the Multiethnic Cohort Study (1,615 cases and 1,962 controls). The single nucleotide polymorphism...

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Identifiers

PMID: 17440066
DOI: 10.1158/0008-5472.CAN-06-4801

Genes

POR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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