Article
Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice.
Proceedings of the National Academy of Sciences of the United States of America - 18 Jan 2011
Waisberg Michael, Tarasenko Tatyana, Vickers Brandi K, Scott Bethany L, Willcocks Lisa C, Molina-Cruz Alvaro, Pierce Matthew A, Huang Chiung-yu, Torres-Velez Fernando J, Smith Kenneth G C, Barillas-Mury Carolina, Miller Louis H, Pierce Susan K, Bolland Silvia
Abstract excerpt
Plasmodium falciparum has exerted tremendous selective pressure on genes that improve survival in severe malarial infections. Systemic lupus erythematosus (SLE) is an autoimmune disease that is six to eight times more prevalent in women of African descent than in women of European descent. Here w...
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