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Article

Effect of amplification of desensitized purF and prs on inosine accumulation in Escherichia coli.

Journal of bioscience and bioengineering - 1 Mar 2007

Shimaoka Megumi, Takenaka Yasuhiro, Kurahashi Osamu, Kawasaki Hisashi, Matsui Hiroshi

Abstract excerpt

The effect of a phosphoribosylpyrophosphate (PRPP) synthetase gene (prs) that was desensitized to feedback inhibition by ADP on inosine accumulation was investigated using an inosine-producing mutant of Escherichia coli. At the same time, various types of plasmid having a PRPP amidotransferase gene (purF) that was desensitized to feedback inhibition by AMP and GMP were also investigated to improve inosine...

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Identifiers

PMID: 17434429
DOI: 10.1263/jbb.103.255

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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