Article
Adaptive mutations in Salmonella typhimurium phenotypic of purR super-repression.
Mutation research - 20 Mar 2006
Yang Zhiwei, Lu Zhong, Wang Aoquan
Abstract excerpt
Under non-lethal selective conditions, a non-dividing or very slowly dividing microbial population gives rise to mutations that relieve selective pressures. This process is described as adaptive mutation. Salmonella typhimurium strain 5-28 has been used as a system for studying adaptive mutations in the chromosomal regulatory gene purR and its target, the purD operator. When this strain is plated on a minimal...
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