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Article

Genetic defects affecting lymphocyte cytotoxicity.

Current opinion in immunology - 1 Jun 2007

Fischer Alain, Latour Sylvain, de Saint Basile Geneviève

Abstract excerpt

Cytolytic lymphocytes kill virus-infected cells as well as tumor cells by the exocytosis of the content of specialized secretory lysosomes at the immunological synapse (IS). Perforin and granzymes are the molecular effectors that induce rapid target cell death. Cytolytic T cells are activated by specific antigen recognition whereas the cytolytic activity of natural killer cells is initiated by specific activating...

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PMID: 17433652
DOI: 10.1016/j.coi.2007.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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