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Article

Perforin deficiency and susceptibility to cancer.

Cell death and differentiation - 1 Apr 2010

Brennan A J, Chia J, Trapani J A, Voskoboinik I

Abstract excerpt

Cytotoxic lymphocytes (CLs) are the killer cells that destroy intracellular pathogen-infected and transformed cells, predominantly through the cytotoxic granule-mediated death pathway. Soluble cytotoxic granule components, including pore-forming perforin and pro-apoptotic serine proteases, granzymes, synergize to induce unscheduled apoptosis of the target cell. A complete loss of CL function results in an...

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Source

Identifiers

PMID: 20075937
DOI: 10.1038/cdd.2009.212

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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