Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA.

PLoS pathogens - 1 Apr 2007

Perrin Robyn M, Fedorova Natalie D, Bok Jin Woo, Cramer Robert A, Wortman Jennifer R, Kim H Stanley, Nierman William C, Keller Nancy P

Abstract excerpt

Secondary metabolites, including toxins and melanins, have been implicated as virulence attributes in invasive aspergillosis. Although not definitively proved, this supposition is supported by the decreased virulence of an Aspergillus fumigatus strain, DeltalaeA, that is crippled in the production of numerous secondary metabolites. However, loss of a single LaeA-regulated toxin, gliotoxin, did not recapitulate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aspergillus fumigatus
Share to Chromosomes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Fungal

Share to Genes, Fungal

Share to Peptide Synthases

Share to RNA, Fungal

Share to Siderophores

Source

Open in PubMed Open full text

Identifiers

PMID: 17432932
DOI: 10.1371/journal.ppat.0030050
PMCID: PMC1851976

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional regulation of chemical diversity in Aspergillus fumigatus by LaeA.PMID 17432932Read ↗

Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species.Semantic proximity Read ↗

LaeA, a regulator of morphogenetic fungal virulence factors.Semantic proximity Read ↗

Gliotoxin, a known virulence factor in the major human pathogen <i>Aspergillus fumigatus</i> , is also biosynthesized by the non-pathogenic relative <i>A. fischeri</i>Semantic proximity Read ↗

Biosynthetic gene clusters, secondary metabolite profiles, and cards of virulence in the closest nonpathogenic relatives of <i>Aspergillus fumigatus</i>Semantic proximity Read ↗

An LaeA- and BrlA-Dependent Cellular Network Governs Tissue-Specific Secondary Metabolism in the Human Pathogen Aspergillus fumigatusSemantic proximity Read ↗

Targeted disruption of nonribosomal peptide synthetase pes3 augments the virulence of Aspergillus fumigatus.Semantic proximity Read ↗

Sub-Telomere Directed Gene Expression during Initiation of Invasive AspergillosisSemantic proximity Read ↗

The Aspergillus fumigatus transcription factor RglT is important for gliotoxin biosynthesis and self-protection, and virulenceSemantic proximity Read ↗

Regulation of gliotoxin biosynthesis and protection in Aspergillus speciesSemantic proximity Read ↗

LaeA, a global regulator of <i>Aspergillus</i> toxinsSemantic proximity Read ↗

Exploration of the Regulatory Mechanism of Secondary Metabolism by Comparative Transcriptomics in Aspergillus flavusSemantic proximity Read ↗

Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.