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Article

Identification of cryptic products of the gliotoxin gene cluster using NMR-based comparative metabolomics and a model for gliotoxin biosynthesis.

Journal of the American Chemical Society - 29 Jun 2011

Forseth Ry R, Fox Ellen M, Chung DaWoon, Howlett Barbara J, Keller Nancy P, Schroeder Frank C

Abstract excerpt

Gliotoxin, a major product of the gli non-ribosomal peptide synthetase gene cluster, is strongly associated with virulence of the opportunistic human pathogen Aspergillus fumigatus. Despite identification of the gli cluster, the pathway of gliotoxin biosynthesis has remained elusive, in part because few potential intermediates have been identified. In addition, previous studies suggest that knowledge of...

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Identifiers

PMID: 21612254
DOI: 10.1021/ja2029987
PMCID: PMC3151163

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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