Article
LaeA, a global regulator of <i>Aspergillus</i> toxins
1 Jan 2006
Abstract excerpt
Several toxins have been implicated in Aspergillus fumigatus pathogenicity. Among these are gliotoxin, fumagillin, fumagatin, and helvolic acid. Recently we have identified a nuclear protein, LaeA, that regulates the production of all of these metabolites. Several criteria support the role of LaeA as a potent A. fumigatus virulence factor. Among these are a decreased ability of the laeA deletion strain (ΔlaeA) to...
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