Article
Variation Among Biosynthetic Gene Clusters, Secondary Metabolite Profiles, and Cards of Virulence Across Aspergillus Species.
Genetics - 1 Oct 2020
Steenwyk Jacob L, Mead Matthew E, Knowles Sonja L, Raja Huzefa A, Roberts Christopher D, Bader Oliver, Houbraken Jos, Goldman Gustavo H, Oberlies Nicholas H, Rokas Antonis
Abstract excerpt
Aspergillus fumigatus is a major human pathogen. In contrast, Aspergillus fischeri and the recently described Aspergillus oerlinghausenensis, the two species most closely related to A. fumigatus, are not known to be pathogenic. Some of the genetic determinants of virulence (or "cards of virulence") that A. fumigatus possesses are secondary metabolites that impair the host immune system, protect from host immune...
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