Article
Does glycoprotein IIIa gene (Pl(A)) polymorphism influence clopidogrel resistance? : a study in older patients.
Drugs & aging - 1 Jan 2007
Papp Elod, Havasi Viktoria, Bene Judit, Komlosi Katalin, Talian Gabor, Feher Gergely, Horvath Beata, Szapary Laszlo, Toth Kalman, Melegh Bela
Abstract excerpt
BACKGROUND: Clopidogrel is a potent antiplatelet drug used for secondary prevention after ischaemic cardiovascular or cerebrovascular events. In patients with aspirin (acetylsalicylic acid) intolerance or resistance, it is used as monotherapy. Recent data report that Pl(A) polymorphism of the glycoprotein IIIa gene may account for differences in aspirin-induced antiplatelet effects. An increased degree of...
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