Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential effects of trisomy on brain shape and volume in related aneuploid mouse models

12 Apr 2007

Abstract excerpt

Down syndrome (DS) results from inheritance of three copies of human chromosome 21 (Hsa21). Individuals with DS have a significantly smaller brain size overall and a disproportionately small cerebellum. The small cerebellum is seen in Ts65Dn mice, which have segmental trisomy for orthologs of about half the genes on Hsa21 and provide a genetic model for DS. While small cerebellar size is well-established in mouse...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down syndrome and intellectual disability research
Share to Genomic variations and chromosomal abnormalities
Share to Prenatal Screening and Diagnostics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17431903
DOI: 10.1002/ajmg.a.31721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential effects of trisomy on brain shape and volume in related aneuploid mouse modelsPMID 17431903Read ↗

Down syndrome mouse models Ts65Dn, Ts1Cje, and Ms1Cje/Ts65Dn exhibit variable severity of cerebellar phenotypes.Semantic proximity Read ↗

Overlapping trisomies for human chromosome 21 orthologs produce similar effects on skull and brain morphology of Dp(16)1Yey and Ts65Dn mice.Semantic proximity Read ↗

Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouseSemantic proximity Read ↗

Comparative analysis of craniofacial shape in two mouse models of Down syndrome: Ts65Dn and TcMAC21.Semantic proximity Read ↗

Trisomy for the Down syndrome 'critical region' is necessary but not sufficient for brain phenotypes of trisomic mice.Semantic proximity Read ↗

Triplication of DYRK1A causes retinal structural and functional alterations in Down syndromeSemantic proximity Read ↗

Craniofacial phenotypes in segmentally trisomic mouse models for Down syndrome.Semantic proximity Read ↗

Effects of aneuploidy on skull growth in a mouse model of Down syndromeSemantic proximity Read ↗

Trisomic and allelic differences influence phenotypic variability during development of Down syndrome mice.Semantic proximity Read ↗

Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice.Semantic proximity Read ↗

Mouse models of cognitive disabilities in trisomy 21 (Down syndrome).Semantic proximity Read ↗

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.