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Discovery and genetic localization of Down syndrome cerebellar phenotypes using the Ts65Dn mouse

22 Jan 2000

Abstract excerpt

Down syndrome (DS) is the most common genetic cause of mental retardation and affects many aspects of brain development. DS individuals exhibit an overall reduction in brain size with a disproportionately greater reduction in cerebellar volume. The Ts65Dn mouse is segmentally trisomic for the distal 12-15 Mb of mouse chromosome 16, a region that shows perfect conserved linkage with human chromosome 21, and...

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PMID: 10607830
DOI: 10.1093/hmg/9.2.195

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