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Article

Triplication of DYRK1A causes retinal structural and functional alterations in Down syndrome

19 Mar 2013

Abstract excerpt

Down syndrome (DS) results from the triplication of approximately 300 human chromosome 21 (Hsa21) genes and affects almost all body organs. Children with DS have defects in visual processing that may have a negative impact on their daily life and cognitive development. However, there is little known about the genes and pathogenesis underlying these defects. Here, we show morphometric in vivo data indicating that...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23512985
DOI: 10.1093/hmg/ddt125

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