Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.

Science (New York, N.Y.) - 23 Sept 2005

O'Doherty Aideen, Ruf Sandra, Mulligan Claire, Hildreth Victoria, Errington Mick L, Cooke Sam, Sesay Abdul, Modino Sonie, Vanes Lesley, Hernandez Diana, Linehan Jacqueline M, Sharpe Paul T, Brandner Sebastian, Bliss Timothy V P, Henderson Deborah J, Nizetic Dean, Tybulewicz Victor L J, Fisher Elizabeth M C

Abstract excerpt

Aneuploidies are common chromosomal defects that result in growth and developmental deficits and high levels of lethality in humans. To gain insight into the biology of aneuploidies, we manipulated mouse embryonic stem cells and generated a trans-species aneuploid mouse line that stably transmits a freely segregating, almost complete human chromosome 21 (Hsa21). This "transchromosomic" mouse line, Tc1, is a model...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aneuploidy
Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Down Syndrome

Share to Facial Bones

Share to Long-Term Potentiation

Share to Maze Learning

Share to Memory

Source

Open in PubMed Open full text

Identifiers

PMID: 16179473
DOI: 10.1126/science.1114535
PMCID: PMC1378183

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An aneuploid mouse strain carrying human chromosome 21 with Down syndrome phenotypes.PMID 16179473Read ↗

A non-mosaic humanized mouse model of Down syndrome, trisomy of a nearly complete long arm of human chromosome 21 in mouse chromosome backgroundSemantic proximity Read ↗

A non-mosaic transchromosomic mouse model of Down syndrome carrying the long arm of human chromosome 21Semantic proximity Read ↗

The first transchromosomic rat model with human chromosome 21 shows robust Down syndrome featuresSemantic proximity Read ↗

Developmental defects in trisomy 21 and mouse models.Semantic proximity Read ↗

Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome.Semantic proximity Read ↗

A new mouse model for Down syndrome.Semantic proximity Read ↗

Mouse-based genetic modeling and analysis of Down syndromeSemantic proximity Read ↗

Impairments in motor coordination without major changes in cerebellar plasticity in the Tc1 mouse model of Down syndromeSemantic proximity Read ↗

Massively Parallel Sequencing Reveals the Complex Structure of an Irradiated Human Chromosome on a Mouse Background in the Tc1 Model of Down SyndromeSemantic proximity Read ↗

Down syndrome mouse models are looking up.Semantic proximity Read ↗

Transchromosomal mouse embryonic stem cell lines and chimeric mice that contain freely segregating segments of human chromosome 21.Semantic proximity Read ↗

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling Down syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.