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Article

Hyperhomocysteinemia and MTHFR polymorphisms in association with orofacial clefts and congenital heart defects: a meta-analysis.

American journal of medical genetics. Part A - 1 May 2007

Verkleij-Hagoort Anna, Bliek Johannes, Sayed-Tabatabaei Fakhredin, Ursem Nicolette, Steegers Eric, Steegers-Theunissen Régine

Abstract excerpt

Several studies have reported an association between hyperhomocysteinemia, 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms and cleft lip with or without cleft palate (CLP), and congenital heart defects (CHDs). However, findings have been inconsistent. A meta-analysis was performed of published studies until September 2006 investigating these associations in both mothers and children. Homocysteine...

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Identifiers

PMID: 17431894
DOI: 10.1002/ajmg.a.31684

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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