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Article

Functional profiling of uncommon VCAM1 promoter polymorphisms prevalent in African American populations.

Human mutation - 1 Aug 2007

Idelman Gila, Taylor James G, Tongbai Ron, Chen Renee A, Haggerty Cynthia M, Bilke Sven, Chanock Stephen J, Gardner Kevin

Abstract excerpt

Multiple variants of the vascular adhesion molecule-1 (VCAM1) promoter show increased nucleotide heterozygosity in the African American population. Using a novel transfection-based transcriptional pathway profiling method, we show that select uncommon variants are functionally hyperactive. Eight candidate VCAM1 promoter haplotypes comprising 13 previously identified SNPs were assessed for response to known...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17431880
DOI: 10.1002/humu.20523

Genes

VCAM1
ETS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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