Article
Molecular prioritization strategies to identify functional genetic variants in the cardiovascular disease-associated expression QTL Vanin-1.
European journal of human genetics : EJHG - 1 May 2014
Kaskow Belinda J, Diepeveen Luke A, Proffitt J Michael, Rea Alexander J, Ulgiati Daniela, Blangero John, Moses Eric K, Abraham Lawrence J
Abstract excerpt
There is now good evidence that non-coding sequence variants are involved in the heritability of many common complex traits. The current 'gold standard' approach for assessing functionality is the in vitro reporter gene assay to assess allelic differences in transcriptional activity, usually foll...
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