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Article

Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2007

Wang Jing, Pan Shi, Berk Bradford C

Abstract excerpt

OBJECTIVE: The glutathione (GSH)/glutaredoxin (Grx) system regulates activities of many redox sensitive enzymes. This system has been shown to protect cells from hydrogen peroxide-induced apoptosis by regulating the redox state of Akt. Grx can be regulated by redox state; the oxidized Grx is selectively recycled to the reduced form by GSH. Flow can maintain endothelial cells in a reduced state by activating...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Nitric Oxide Synthase Type III

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Source

Identifiers

PMID: 17431186
DOI: 10.1161/ATVBAHA.107.144659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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