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Article

Molecular Mechanisms of Neutrophil-Endothelial Cell Adhesion Induced by Redox Imbalance

19 Mar 1999

Abstract excerpt

Previous studies have implicated a role for intracellular thiols in the activation of nuclear factor-kappaB and transcriptional regulation of endothelial cell adhesion molecules. This study was designed to determine whether changes in endothelial cell glutathione (GSH) or oxidized glutathione (GSSG) can alter neutrophil adhesivity and to define the molecular mechanism that underlies this GSSG/GSH-induced adhesion...

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PMID: 10082473
DOI: 10.1161/01.res.84.5.516

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