Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HoxA10 Activates Transcription of the Gene Encoding Mitogen-activated Protein Kinase Phosphatase 2 (Mkp2) in Myeloid Cells

13 Apr 2007

Abstract excerpt

HoxA10 is a homeodomain transcription factor that is frequently overexpressed in human acute myeloid leukemia. In murine bone marrow transplantation studies, HoxA10 overexpression induces a myeloproliferative disorder with accumulation of mature phagocytes in the peripheral blood and tissues. Over time, differentiation block develops in these animals, resulting in acute myeloid leukemia. In immature myeloid...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Histone Deacetylase Inhibitors Research
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17430893
DOI: 10.1074/jbc.m610556200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HoxA10 Activates Transcription of the Gene Encoding Mitogen-activated Protein Kinase Phosphatase 2 (Mkp2) in Myeloid CellsPMID 17430893Read ↗

Constitutively active SHP2 cooperates with HoxA10 overexpression to induce acute myeloid leukemia.Semantic proximity Read ↗

Activation of SHP2 protein-tyrosine phosphatase increases HoxA10-induced repression of the genes encoding gp91(PHOX) and p67(PHOX).Semantic proximity Read ↗

MiR-10a and HOXB4 are overexpressed in atypical myeloproliferative neoplasmsSemantic proximity Read ↗

The transcriptome of the leukemogenic homeoprotein HOXA9 in human hematopoietic cellsSemantic proximity Read ↗

Methylation of Dual Specificity Phosphatase 4 Controls Cell DifferentiationSemantic proximity Read ↗

The stem cell–specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemiaSemantic proximity Read ↗

Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defectsSemantic proximity Read ↗

HOXA11 plays critical roles in disease progression and response to cytarabine in AML.Semantic proximity Read ↗

Dual Specificity Phosphatase 3 knockdown drives myeloid leukemia cells to differentiate into macrophages and polarizeSemantic proximity Read ↗

Tight control of MEK-ERK activation is essential in regulating proliferation, survival, and cytokine production of CD34+-derived neutrophil progenitors.Semantic proximity Read ↗

The role of HOX genes in malignant myeloid diseaseSemantic proximity Read ↗

Genome-wide analysis of gene-expression profiles in chronic myeloid leukemia cells using a cDNA microarraySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.