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Article

The role of HOX genes in malignant myeloid disease

25 Jan 2007

Abstract excerpt

PURPOSE OF REVIEW: The Hox family of homeodomain transcription factors plays an important role in regulating definitive hematopoiesis. Recent studies indicate that a common characteristic of poor prognosis acute myeloid leukemia is dysregulated expression of a key group of these Hox proteins. The purpose of this review is to outline recent progress in understanding the role that dysregulation of HOX-gene...

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PMID: 17255784
DOI: 10.1097/moh.0b013e32801684b6

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