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Article

HOXA11 plays critical roles in disease progression and response to cytarabine in AML.

Oncology reports - 1 Jul 2021

Fu Jen-Fen, Shih Lee-Yung, Yen Tzung-Hai

Abstract excerpt

Lysine methyltransferase 2A (KMT2A, also known as MLL) translocations (MLL‑t) are frequently associated with mutations in RAS pathway genes in acute myeloid leukemia (AML). Previous findings with a mouse model showed that cooperation of MLL/AF10 with tyrosine‑protein phosphatase non‑receptor type 11 (PTPN11)G503A accelerated leukemia development, but increased cytarabine (Ara‑C) sensitivity of leukemia cells. To...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34080665
DOI: 10.3892/or.2021.8101
PMCID: PMC8185505

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