Article
Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study.
Breast cancer research : BCR - 1 Jan 2007
Broeks Annegien, Braaf Linde M, Huseinovic Angelina, Nooijen Anke, Urbanus Jos, Hogervorst Frans B L, Schmidt Marjanka K, Klijn Jan G M, Russell Nicola S, Van Leeuwen Flora E, Van 't Veer Laura J
Abstract excerpt
INTRODUCTION: Radiation exposure at a young age is one of the strongest risk factors for breast cancer. Germline mutations in genes involved in the DNA-damage repair pathway (DDRP) may render women more susceptible to radiation-induced breast cancer. METHODS: We evaluated the contribution of germline mutations in the DDRP genes BRCA1, BRCA2, CHEK2 and ATM to the risk of radiation-induced contralateral breast...
Topics
- Adult
- Ataxia Telangiectasia Mutated Proteins
- Breast Neoplasms
- Cell Cycle Proteins
- Checkpoint Kinase 2
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Female
- Genes, BRCA1