Article
Radiation Treatment, ATM, BRCA1/2, and CHEK2*1100delC Pathogenic Variants and Risk of Contralateral Breast Cancer.
Journal of the National Cancer Institute - 14 Dec 2020
Reiner Anne S, Robson Mark E, Mellemkjær Lene, Tischkowitz Marc, John Esther M, Lynch Charles F, Brooks Jennifer D, Boice John D, Knight Julia A, Teraoka Sharon N, Liang Xiaolin, Woods Meghan, Shen Ronglai, Shore Roy E, Stram Daniel O, Thomas Duncan C, Malone Kathleen E, Bernstein Leslie, Riaz Nadeem, Woodward Wendy, Powell Simon, Goldgar David, Concannon Patrick, Bernstein Jonine L
Abstract excerpt
Whether radiation therapy (RT) affects contralateral breast cancer (CBC) risk in women with pathogenic germline variants in moderate- to high-penetrance breast cancer-associated genes is unknown. In a population-based case-control study, we examined the association between RT; variants in ATM, BRCA1/2, or CHEK2*1100delC; and CBC risk. We analyzed 708 cases of women with CBC and 1399 controls with unilateral...
Topics
- Adult
- Ataxia Telangiectasia Mutated Proteins
- BRCA1 Protein
- BRCA2 Protein
- Breast Neoplasms
- Case-Control Studies
- Checkpoint Kinase 2
- Female