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Article

Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study.

Human mutation - 1 Jan 2012

Brooks Jennifer D, Teraoka Sharon N, Reiner Anne S, Satagopan Jaya M, Bernstein Leslie, Thomas Duncan C, Capanu Marinela, Stovall Marilyn, Smith Susan A, Wei Shan, Shore Roy E, Boice John D, Lynch Charles F, Mellemkjaer Lene, Malone Kathleen E, Liang Xiaolin, Haile Robert W, Concannon Patrick, Bernstein Jonine L

Abstract excerpt

Ionizing radiation (IR) is a breast carcinogen that induces DNA double-strand breaks (DSBs), and variation in genes involved in the DNA DSB response has been implicated in radiation-induced breast cancer. The Women's Environmental, Cancer, and Radiation Epidemiology (WECARE) study is a population-based study of cases with contralateral breast cancer (CBC) and matched controls with unilateral breast cancer. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21898661
DOI: 10.1002/humu.21604
PMCID: PMC3240722

Genes

RAD50
ATM
CHEK2
MDC1
NBN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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