Diagnostic and therapeutic ionizing radiation and the risk of a first and second primary breast cancer, with special attention for BRCA1 and BRCA2 mutation carriers: a critical review of the literature.

Abstract excerpt

Occurrence of breast cancer is a well-known long-term side effect of ionizing radiation (both diagnostic and therapeutic). The radiation-induced breast cancer risk increases with longer follow-up, higher radiation dose and younger age of exposure. The risk for breast cancer following irradiation for lymphomas is well known. Although data regarding the carcinogenic risk of adjuvant radiotherapy for a primary...

Topics

• Breast Neoplasms
• Dose-Response Relationship, Radiation
• Female
• Genes, BRCA1
• Genes, BRCA2
• Genetic Predisposition to Disease
• Heterozygote
• Humans
• Mammography
• Mutation