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Article

WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing.

The Journal of cell biology - 3 Jan 2022

De-Castro Ana R G, Rodrigues Diogo R M, De-Castro Maria J G, Vieira Neide, Vieira Cármen, Carvalho Ana X, Gassmann Reto, Abreu Carla M C, Dantas Tiago J

Abstract excerpt

The dynein-2 motor complex drives retrograde intraflagellar transport (IFT), playing a pivotal role in the assembly and functions of cilia. However, the mechanisms that regulate dynein-2 motility remain poorly understood. Here, we identify the Caenorhabditis elegans WDR60 homologue, WDR-60, and dissect the roles of this intermediate chain using genome editing and live imaging of endogenous dynein-2/IFT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34739033
DOI: 10.1083/jcb.202010178
PMCID: PMC8576871

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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